【药物名称】商品名：莽草酸
通用名：拜邦蝉联莽草酸（禽流感克星）
【主要成分】苦杏仁、石膏、麻黄、洋金花。
【性 状】类白色精细粉末，易溶于水，在水中的溶解度为18g/100mL，难溶于氯仿、苯和石油醚，气味辛酸，味苦。
【分子结构】化学式：3,4,5-三羟基-1-环己烯-1-羧酸 分子式： C7H10O5分子量：174.15 。
【功 能】止咳、平喘、清热解毒、辛凉解表、等提高免疫力。
【主 治】本品为抗病毒类药。适用于鸡、鸭、鹅、猪，对各种DNA和RNA病毒性疾病均有较强抑制作用，特别对由H5N1、H9N2等亚型流感病毒引起的流行性感冒有治疗和预防的作用。
主要用于防治禽流行性感冒、传染性支气管炎、传染性喉气管炎、新城疫、传染性法氏囊、鸭肝、鸭瘟、脾坏死、副粘病毒、猪流感、猪瘟、等病毒性疾病。尤其对病毒病和细菌病混合感染（如气囊炎病）疗效确切。采食下降、精神沉郁、甩头、流泪、咳嗽、呼噜、呼吸困难、肢体瘫痪、站立不稳、排黄白绿色粪便产蛋率下降等。
【产品特点】莽草酸可以直接通过影响花生四烯酸代谢，抑制血小板聚集，抑制动、静脉血栓及脑血栓形成发挥作用，莽草酸还具有抗炎、镇痛作用。莽草酸可以作为抗病毒和抗癌药物中间体，在体内莽草酸还可转化为多种对病毒、细菌和癌细胞有抑杀作用的物质。 风靡全球达菲就是通过莽草酸进一步衍生化得到的。专家称这是世界上对付禽流感的唯一
武器。因其口服吸收好，生物利用度高，抗病毒效果可靠。
全面替代金刚烷胺，安全高效，疗效是金刚烷胺的3—5倍。本产品绝不含利巴韦林、金刚烷胺等国家禁用抗病毒药物亦不含地米、扑尔敏、吲哚美辛等解表药物，是养殖首选，可用于出口鸡场、猪场。
流感病毒在宿主细胞内复制表达和组装之后，会以出芽的形式突出宿主细胞，但与宿主细胞以凝血酶-唾液酸相连接，神经氨酸酶以唾液酸为作用底物，可催化唾液酸水解，解除成熟病毒颗粒与宿主细胞之间的联系，使之可以自由移动侵袭其他健康的宿主细胞。如果抑制神经氨酸酶的活性可以阻止病毒颗粒的释放，切断病毒的扩散链，从而抑制病毒的复制。在发病后24小时内使用，病程会减短20%-30%，病情会减轻25%，作为预防用药，对流感病毒暴露者的保护率在60%-80%之间。另外还可以通过阻断病毒的糖蛋白合成及抑制病毒成熟后从细胞的释放达到抗病毒效果。
口服迅速被吸收，进入血液循环，2～3小时后达血药峰浓度，其在体内可以定向分布至肺部、支气管、鼻窦、中耳等部位。
【用法用量】混饮 禽、猪每袋兑水350kg连用3-5天。 混饲 禽、猪每袋拌料175kg连用3-5天。
【注意事项】 1. 本品极易吸潮，开袋后应尽快用完。
2. 原料若有结块，可于70℃烘干1h，粉碎过筛后使用。
【不良反应】 暂无。
【规 格】 ≥98%；100g/瓶。
【贮 存】 遮光、密闭保存。
美国拜邦生物科技集团有限公司 地址：南京市沿江工业开发区新华路
电话：025-81650492 招商热线：18751886846
[medicine name] commodity name: shikimic acid
Common name: thanks to the state won the shikimic acid (avian influenza.)
[main ingredients] bitter almond, plaster, ephedra, Flos daturae.
[character] class fine white powder, soluble in water, solubility is 18g/100mL in water, insoluble in chloroform, benzene, and petroleum ether, smell of bitter, bitter taste.
[] the molecular structure of chemical formula: 3,4,5- three hydroxy -1- cyclohexene -1- carboxylic acid molecular formula: C7H10O5 molecular weight: 174.15.
[function] relieving cough and asthma, detoxification, pungent-cool diaphoretic, and improve immunity.
[treatment] this product for antiviral drugs. Suitable for chicken, duck, goose, pig, for both DNA and RNA viral disease inhibitory effect, especially for treatment and prevention of influenza caused by the H5N1, H9N2 subtype influenza virus effect. Mainly used for prevention and control of avian influenza, infectious bronchitis, infectious laryngotracheitis, Newcastle disease, infectious bursal, duck, duck plague, spleen necrosis, paramyxovirus, swine flu, swine fever, viral diseases such as. Especially for viral and bacterial diseases of mixed infections (such as airsacculitis disease) curative effect. Food intake decreased, depression, shook his head, tears, cough, difficulty breathing, snoring, paralysis of limbs, standing instability, rows of yellow and white green manure laying rate drop.
[features] shikimic acid can be directly affected by four arachidonic acid metabolism, inhibit platelet aggregation, inhibit, venous thrombosis and cerebral thrombosis play a role, shikimic acid also has anti-inflammatory, analgesic effect. Shikimic acid can be used as antiviral and anticancer drug intermediates, in vivo shikimic acid can also be converted into a wide variety of viruses, bacteria and cancer cells to kill the substance. Swept the world of Tamiflu is through further derivatization of shikimic acid. Experts say this is the only weapon against avian influenza. Because of its good oral absorption, high bioavailability, antiviral effect is reliable.
Replace amantadine, high safety, efficacy is 3 - 5 times the amantadine. This product contains no ribavirin, amantadine and other countries banned antiviral drugs also does not contain more meters, chlorpheniramine, indomethacin, diaphoretic drug, is the culture choice, can be used for export of farms, pig farms.
After influenza virus replication in host cells expression and assembly, to host cells form prominent budding, but with the host cells to thrombin - sialic acid is connected, neuraminidase to sialic acid as substrate, can catalyze the sialic acid hydrolysis, releasing between mature virus particles and host cell contact, which can move freely invasion other healthy host cells. If the inhibition of neuraminidase activity can prevent the release of virus particles, to cut off the spread of the virus, thereby inhibiting virus replication. In 24 hours after the onset, duration will shorten 20%-30%, disease will be reduced by 25%, as a preventive medication, the influenza virus exposure protection rate was 60%-80%. Can also be through blocking and inhibiting virus glycoprotein synthesis of virus maturation from cells can release the antiviral effect in addition.
Oral is rapidly absorbed, enter the blood circulation, 2 ~ 3 hours after the peak plasma concentration, the directional distribution to the lungs, bronchial, sinus, middle ear and other parts of the body.
[usage] mix of avian, swine each bag exchange water 350kg 3-5 day. Mixed feeding poultry, pigs each bag of mixing 175KG 3-5 day.
[note] 1 the hygroscopic, open the bag should run out as soon as possible.
2 raw material if there is agglomeration, in 70 ℃ drying 1H, crushed and sieved using.
[] no adverse reaction.
[Specification] = 98%; 100g/ bottle.
[storage] shading, airtight preservation.
The United States of America thanks to the state of Biological Technology Group Co., Ltd.
